Carbon Dioxide → HCID 54105642, compound

HRID 223221Notes

Reaction equation

HRID 223221 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[N:13][C:14](C(O)=O)=[C:10]3[C@@H:9]3[CH2:18][CH2:19][CH2:20][N:8]3[C:7](=[O:21])[C:6]=2[CH:22]=1.C(=O)=O>C(OCC)(=O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[N:13][CH:14]=[C:10]3[C@@H:9]3[CH2:18][CH2:19][CH2:20][N:8]3[C:7](=[O:21])[C:6]=2[CH:22]=1

Participants

4

Reactant 2

HCID 280Carbon DioxideHCID 54231756HCID 54231756, compound

Product 1

HCID 54105642HCID 54105642, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5.8 g (18.2 mmol) of (S)-7-chloro-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid are heated to 230°. After completion of the carbon dioxide evolution, the melt is treated with ethyl acetate. The solid material is filtered off under suction and dried. There is obtained (S)-7-chloro-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one of melting point 216°-217°.

Workup

  1. filtrationThe solid material is filtered off under suction
  2. customdried

Sources & evidence

ORD record
ord-f80178c66351421f9f8f58658c049ace
Source dataset
uspto-grants-1982_10
Patent number
US04352818

Reaction notes

Loading…