Pyrrolidine → 1,2,4-Triazolo(3,4-a)phthalazine, 6-phenyl-3-(1-pyrrolidinyl)-

HRID 2232230Notes

Reaction equation

HRID 2232230 reaction equation
Cl[C:2]1[N:6]2[N:7]=[C:8]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:9]3[C:14]([C:5]2=[N:4][N:3]=1)=[CH:13][CH:12]=[CH:11][CH:10]=3.[NH:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1>C(O)C>[C:15]1([C:8]2[C:9]3[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=3)[C:5]3=[N:4][N:3]=[C:2]([N:21]4[CH2:25][CH2:24][CH2:23][CH2:22]4)[N:6]3[N:7]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 21283333HCID 21283333, compound

Product 1

HCID 30712411,2,4-Triazolo(3,4-a)phthalazine, 6-phenyl-3-(1-pyrrolidinyl)-

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 3-chloro-6-phenyl-1,2,4-triazolo[3,4-a]phthalazine (4.5 g), pyrrolidine (6 ml) and ethanol (40 ml) is poured in a steel cylinder and heated to 100° C. for 8 hours. Then the mixture is cooled, and concentrated to dryness by evaporating off the solvent. The obtained residue is washed with water and crystallized from ethanol giving 3.5 g of the compound of the title. M.p. 245°-47° C.

Workup

  1. temperatureThen the mixture is cooled
  2. concentrationconcentrated to dryness
  3. customby evaporating off the solvent
  4. washThe obtained residue is washed with water
  5. customcrystallized from ethanol giving 3.5 g of the compound of the title

Sources & evidence

ORD record
ord-d917a64c48e346b78c3c8d66a349178b
Source dataset
uspto-grants-1988_11
Patent number
US04788186

Reaction notes

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