Sodium Hydroxide → 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-2-mercapto-

HRID 2232365Notes

Reaction equation

HRID 2232365 reaction equation
[OH:1][C:2]1[CH:15]=[CH:14][C:5]([CH:6]=[C:7]2[S:11]C(=S)N[C:8]2=[O:13])=[CH:4][C:3]=1[O:16][CH3:17].[OH-:18].[Na+]>Cl>[OH:1][C:2]1[CH:15]=[CH:14][C:5]([CH:6]=[C:7]([SH:11])[C:8]([OH:18])=[O:13])=[CH:4][C:3]=1[O:16][CH3:17]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 28316035447-37-0

Product 1

HCID 27478852-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-2-mercapto-

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

The product from Step A was added to 20% sodium hydroxide solution (250 mL) and heated to 70°-75° C. with stirring for one hour. The resulting solution was chilled in an ice bath and added rapidly, with stirring, to cold 10% hydrochloric acid (350 mL). The yellow solid was collected, washed with water and dried at 50° C.; yield 36 g.

Workup

  1. temperatureheated to 70°-75° C.
  2. temperatureThe resulting solution was chilled in an ice bath
  3. additionadded rapidly
  4. customThe yellow solid was collected
  5. washwashed with water
  6. customdried at 50° C.

Sources & evidence

ORD record
ord-ec4604586f234c3195d83d93c2475c93
Source dataset
uspto-grants-1988_11
Patent number
US04788192

Reaction notes

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