p-Fluoronitrobenzene → HCID 70418345, compound

HRID 2232411Notes

Reaction equation

HRID 2232411 reaction equation
[N:1]1([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([C:13]([NH:15][NH2:16])=[O:14])[CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.F[C:18]1[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=1.C(=O)([O-])[O-].[Na+].[Na+]>CN(C)C=O>[N+:24]([C:21]1[CH:22]=[CH:23][C:18]([N:4]2[CH2:5][CH2:6][N:1]([C:7]3[CH:12]=[CH:11][N:10]=[C:9]([C:13]([NH:15][NH2:16])=[O:14])[CH:8]=3)[CH2:2][CH2:3]2)=[CH:19][CH:20]=1)([O-:26])=[O:25]

Participants

5

Reactant 3

HCID 9590p-FluoronitrobenzeneHCID 10340Sodium CarbonateHCID 57454346HCID 57454346, compound

Product 1

HCID 70418345HCID 70418345, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of the product of (i) above (7.76 g), 4-fluoronitrobenzene (5.50 g) and sodium carbonate (4.50 g) in N,N-dimethylformamide (40 ml) was heated at 100° C. with stirring for 4 hours. The mixture was evaporated to about half volume and filtered. The residue was washed with ethanol followed by warm water and then dried to give the title compound (9.41 g), m.p. 230°-232° C.

Workup

  1. customThe mixture was evaporated to about half volume
  2. filtrationfiltered
  3. washThe residue was washed with ethanol
  4. temperatureby warm water
  5. customdried

Sources & evidence

ORD record
ord-5dcdee8c217c4fccae6b64b1be6e0756
Source dataset
uspto-grants-1988_11
Patent number
US04788196

Reaction notes

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