HCID 88500541, compound → HCID 88500301, compound

HRID 2232436Notes

Reaction equation

HRID 2232436 reaction equation
[NH2:1][C:2]1[S:3][C:4]([Cl:41])=[C:5](/[C:7](=[N:31]/[O:32][CH2:33][C:34]([O:36]C(C)(C)C)=[O:35])/[C:8]([NH:10][C@@H:11]2[C:29](=[O:30])[N:13]3[C:14]([C:26]([OH:28])=[O:27])=[C:15]([CH2:18][O:19][C:20](=[O:25])[CH2:21][C:22](=[O:24])[CH3:23])[CH2:16][S:17][C@H:12]23)=[O:9])[N:6]=1>FC(F)(F)C(O)=O>[NH2:1][C:2]1[S:3][C:4]([Cl:41])=[C:5](/[C:7](=[N:31]/[O:32][CH2:33][C:34]([OH:36])=[O:35])/[C:8]([NH:10][C@@H:11]2[C:29](=[O:30])[N:13]3[C:14]([C:26]([OH:28])=[O:27])=[C:15]([CH2:18][O:19][C:20](=[O:25])[CH2:21][C:22](=[O:24])[CH3:23])[CH2:16][S:17][C@H:12]23)=[O:9])[N:6]=1

Participants

3

Reactant 1

HCID 88500541HCID 88500541, compound

Product 1

HCID 88500301HCID 88500301, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Two grams of 7β-[2-(2-amino-5-chlorothiazol-4-yl)-2(Z)-(tert-butoxycarbonylmethoxyimino)acetamido]-3-(3-oxobutyryloxymethyl)-3-cephem-4-carboxylic acid is dissolved in 20 ml of trifluoroacetic acid. The solution is stirred at room temperature for 1 hour and then evaporated to dryness under reduced pressure to give crude 7β-[2-(2-amino-5-chlorothiazol-4-yl)-2(Z)-(carboxymethoxyimino)acetamido]-3-(3-oxobutyryloxymethyl)-3-cephem-4-carboxylic acid.

Workup

  1. customevaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-dfbed8bb47c346e0b2b736114878c7f1
Source dataset
uspto-grants-1988_11
Patent number
US04788185

Reaction notes

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