Piperazine → 1-(3-Chloro-5-(trifluoromethyl)phenyl)piperazine

HRID 2232928Notes

Reaction equation

Cl[C:2]1[CH:3]=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[Cl:8][C:6]1[CH:7]=[C:2]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[CH:3]=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:5]=1

Participants

Reactant 2

HCID 4837Piperazine

HCID 353611,3-Dichloro-5-(trifluoromethyl)benzene

Product 1

HCID 223451951-(3-Chloro-5-(trifluoromethyl)phenyl)piperazineYield 52.1%

Procedure

Beginning with 3,5-dichlorobenzotrifluoride (500 mg, 2.32 mmol) and piperazine (1 g, 11.6 mmol), 320 mg of the title compound was recovered by the procedure described in Example 1.

Sources & evidence

ORD record: ord-bcf1280cb0754c7fb563a0e18a80ea2f
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: USRE041315E1

Reaction notes

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