Ethanolamine → HCID 68678087, compound

HRID 2233019Notes

Reaction equation

HRID 2233019 reaction equation
[C:1]([C:5]1[N:6]=[C:7](Cl)[C:8]2[N:9]([C:11](=[O:14])[NH:12][N:13]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:16]([CH2:18][NH2:19])[OH:17]>C1COCC1>[C:1]([C:5]1[N:6]=[C:7]([NH:19][CH2:18][CH2:16][OH:17])[C:8]2[N:9]([C:11](=[O:14])[NH:12][N:13]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 68676527HCID 68676527, compound

Product 1

HCID 68678087HCID 68678087, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 0.50 g of the product of Step F and 0.40 g of ethanolamine in THF (6 mL) was heated at reflux for 16 h. After cooling the reaction mixture to ambient temperature, solvents were removed and the residue was purified by silica gel chromatography to yield the title compound as a white solid. MS (M+H+)=252.3.

Workup

  1. temperatureat reflux for 16 h
  2. customsolvents were removed
  3. customthe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-543f1bd9aebb4f73add199eacbf683b5
Source dataset
uspto-grants-2010_05
Patent number
US07709473B2

Reaction notes

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