Isopropylamine → HCID 68676396, compound

HRID 2233033Notes

Reaction equation

HRID 2233033 reaction equation
Br[C:2]1[C:3]2[N:4]([C:14](=[O:17])[NH:15][N:16]=2)[CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1.[CH:18]([NH2:21])([CH3:20])[CH3:19]>C1COCC1>[CH:18]([NH:21][C:2]1[C:3]2[N:4]([C:14](=[O:17])[NH:15][N:16]=2)[CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1)([CH3:20])[CH3:19]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 68675744HCID 68675744, compound

Product 1

HCID 68676396HCID 68676396, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 29 mg of the product of Step A and 118 mg of isopropylamine in THF (5.0 mL) was heated at reflux for 16 h. The reaction was concentrated to one-quarter volume, diluted with water, and the pH was adjusted to pH 2 with 2N HCl. The solid was collected and triturated for one h in isopropyl ether at 60° C. before being collected and dried to give the title compound as a tan solid. MS (M+H+)=270.1.

Workup

  1. temperatureat reflux for 16 h
  2. concentrationThe reaction was concentrated to one-quarter volume
  3. additiondiluted with water
  4. customThe solid was collected
  5. customtriturated for one h in isopropyl ether at 60° C.
  6. custombefore being collected
  7. customdried

Sources & evidence

ORD record
ord-f5a65f1812f04753959047522f27b046
Source dataset
uspto-grants-2010_05
Patent number
US07709473B2

Reaction notes

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