Tetrahydrofuran → HCID 68677253, compound

HRID 2233041Notes

Reaction equation

HRID 2233041 reaction equation
[C:1]([C:5]1[N:6]=[C:7](Cl)[C:8]2[N:9]([C:18](=[O:21])[NH:19][N:20]=2)[C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1C)([CH3:4])([CH3:3])[CH3:2].[N:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH2:29][CH2:30][NH2:31])[CH:24]=1.[CH2:32]1COCC1>>[C:1]([C:5]1[N:6]=[C:7]([NH:31][CH2:30][CH2:29][C:25]2[CH:24]=[N:23][CH:28]=[CH:27][CH:26]=2)[C:8]2[N:9]([C:18](=[O:21])[NH:19][N:20]=2)[C:10]=1[C:11]1[CH:16]=[C:15]([CH3:32])[CH:14]=[CH:13][CH:12]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 8540512-(Pyridin-3-yl)ethan-1-amineHCID 68676862HCID 68676862, compound

Product 1

HCID 68677253HCID 68677253, compound

Procedure

A solution of 31 mg of the product of Step A and 120 mg of 2-pyridin-3-yl-ethylamine in THF (3.0 mL) was heated at reflux for 16 h. The solvent was removed and the residue was purified by silica gel chromatography to afford the title compound as a light yellow solid. MS (M+H+)=403.4.

Workup

  1. temperatureat reflux for 16 h
  2. customThe solvent was removed
  3. customthe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-72c727a5dae4493abd2c41a9e5af5520
Source dataset
uspto-grants-2010_05
Patent number
US07709473B2

Reaction notes

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