反应详情

A solution of chloroacetyl chloride (38.4 ml, 480 mmol) in ethyl acetate (100 ml) was slowly added to a vigorously-stirred mixture of 3-fluoro-2-methylaniline (60 g, 480 mmol), saturated aqueous sodium bicarbonate (400 ml), ice (ca 100 g) and ethyl acetate (400 ml). Some solid formed then dissolved. After 1 hour the mixture was evaporated to removing the ethyl acetate) and filtered, washing with water. The resulting product was dried in vacuo (94.4 g, 98%).

1. customSome solid formed
2. dissolutionthen dissolved
3. customAfter 1 hour the mixture was evaporated
4. customto removing the ethyl acetate) and
5. filtrationfiltered
6. washwashing with water
7. customThe resulting product was dried in vacuo (94.4 g, 98%)