Hydrochloric Acid → 7-Fluoro-8-methyl-2(1H)-quinoxalinone

HRID 2233165Notes

Reaction equation

HRID 2233165 reaction equation
[F:1][C:2]1[C:3]([CH3:16])=[C:4]2[C:9](=[CH:10][CH:11]=1)[N+:8]([O-])=[C:7](C#N)[C:6](=[O:15])[NH:5]2.S(S([O-])=O)([O-])=O.[Na+].[Na+].C#N.Cl.[OH-].[Na+]>C(O)C.O>[F:1][C:2]1[C:3]([CH3:16])=[C:4]2[C:9]([N:8]=[CH:7][C:6](=[O:15])[NH:5]2)=[CH:10][CH:11]=1

Participants

8

Reactant 5

HCID 313Hydrochloric AcidHCID 768Hydrogen CyanideHCID 14798Sodium HydroxideHCID 24489Sodium DithioniteHCID 86628358HCID 86628358, compound

Product 1

HCID 451217207-Fluoro-8-methyl-2(1H)-quinoxalinoneYield 81.1%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of 6-fluoro-5-methyl-3-oxo-3,4-dihydro-2-quinoxalinecarbonitrile 1-oxide (15.9 g, 71.8 mmol) and sodium dithionite (36.7 g, 179.6 mmol) in ethanol (200 ml) and water (400 ml) was heated under reflux for 1 h, with a flow of argon over the top of the condenser leading to a bleach-filled bottle to trap HCN. The cooled mixture was carefully acidified to pH1 with dilute HCl and the mixture was stirred for 45 min at RT. Sodium hydroxide (50% aqueous) was then added to give pH˜11 and the mixture was evaporated to remove approx. 500 ml. The residue was acidified to pH 6 with dilute HCl (caution: cyanide still present!) and the precipitate was filtered off, washed with water and dried to give a solid (10.37 g, 81%). Extraction of the aqueous liquor with 10% methanol/dichloromethane and evaporation of the extracts gave a further small amount of product (0.8 g). Total yield 11.2 g, 88%.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 1 h, with a flow of argon over the top of the condenser
  3. customleading to a bleach-filled bottle to trap
  4. customto give pH˜11
  5. customthe mixture was evaporated
  6. customto remove approx. 500 ml
  7. filtration) and the precipitate was filtered off
  8. washwashed with water
  9. customdried

Sources & evidence

ORD record
ord-b55c73d9960942e2a4c9288e36f6bc0e
Source dataset
uspto-grants-2010_05
Patent number
US07709483B2

Reaction notes

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