Hydrochloric Acid → HCID 68448342, compound

HRID 2233189Notes

Reaction equation

HRID 2233189 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[CH:7][C:6](=[O:12])[N:5]3[CH2:13][CH:14]([CH2:15][N:16]4[CH2:21][CH2:20][CH:19]([NH:22][CH2:23][C:24]5[N:40]=[CH:39][C:27]6[O:28][CH2:29][CH2:30][N:31](C(OC(C)(C)C)=O)[C:26]=6[CH:25]=5)[CH2:18][CH2:17]4)[C:3]=1[C:4]=23.[ClH:41]>ClCCl.CO.O1CCOCC1>[ClH:41].[ClH:41].[NH:31]1[CH2:30][CH2:29][O:28][C:27]2[CH:39]=[N:40][C:24]([CH2:23][NH:22][CH:19]3[CH2:18][CH2:17][N:16]([CH2:15][CH:14]4[C:3]5[C:4]6[N:5]([C:6](=[O:12])[CH:7]=[N:8][C:9]=6[CH:10]=[CH:11][C:2]=5[F:1])[CH2:13]4)[CH2:21][CH2:20]3)=[CH:25][C:26]1=2

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 68449802HCID 68449802, compound

Product 1

HCID 68448342HCID 68448342, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

1,1-Dimethylethyl 7-[({1-[(7-fluoro-3-oxo-5,6-dihydro-3H-pyrrolo[1,2,3-de]quinoxalin-6-yl)methyl]-4-piperidinyl}amino)methyl]-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazine-1-carboxylate (91 mg, 0.165 mmol) in dichloromethane (2 ml) and methanol (1.5 ml) was treated with 4M hydrogen chloride in 1,4-dioxane (3.5 ml). After standing at room temperature for 2.5 h, the mixture was evaporated. The residue was triturated twice with ether and dried to give the title compound (89 mg).

Workup

  1. customthe mixture was evaporated
  2. customThe residue was triturated twice with ether
  3. customdried

Sources & evidence

ORD record
ord-372cd51962c8404cb3285e7e94551fb2
Source dataset
uspto-grants-2010_05
Patent number
US07709483B2

Reaction notes

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