反应详情

0.30 g Lithium aluminum hydride was dissolved in 10 ml dry tetrahydrofuran. 2.0 g 4-Methyl-2-(1-methyl-cyclohexyl)-oxazole-5-carboxylic acid ethyl ester, dissolved in 20 ml tetrahydrofuran, were added. The reaction mixture was stirred at room temperature over a period of one hour, then 50 ml ethyl acetate and 50 ml saturated ammonium chloride solution were added to the ice cooled mixture. The reaction mixture was extracted five times with portions of 60 ml of ethyl acetate. The combined organic layers were dried over MgSO4 and the solvent removed under reduced pressure to provide 1.54 g [4-Methyl-2-(1-methyl-cyclohexyl)-oxazol-5-yl]-methanol as an oil.

1. additionwere added
2. temperaturecooled mixture
3. extractionThe reaction mixture was extracted five times with portions of 60 ml of ethyl acetate
4. dry with materialThe combined organic layers were dried over MgSO4
5. customthe solvent removed under reduced pressure