Hydrochloric Acid → HCID 86628019, compound

HRID 2233343Notes

Reaction equation

HRID 2233343 reaction equation
[O:1]=[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([CH2:12][CH2:13][N:14]3[CH2:19][CH2:18][CH:17]([NH:20]C(=O)OC(C)(C)C)[CH2:16][CH2:15]3)[CH:6]=[CH:7][CH:8]=2)[O:3]1.[ClH:28]>CO.C(Cl)Cl.O1CCOCC1>[ClH:28].[NH2:20][CH:17]1[CH2:18][CH2:19][N:14]([CH2:13][CH2:12][C:5]2[CH:6]=[CH:7][CH:8]=[C:9]3[C:4]=2[O:3][C:2](=[O:1])[CH:11]=[CH:10]3)[CH2:15][CH2:16]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57585666HCID 57585666, compound

Product 1

HCID 86628019HCID 86628019, compoundYield 73%

Reagents, catalysts & solvents 2

HCID 312751,4-DioxaneSolventHCID 21226129Dichloromethane methanolSolvent

Procedure

To a solution of (1,1-dimethylethyl {1-[2-(2-oxo-2H-chromen-8-yl)ethyl]-4-piperidinyl}carbamate (320 mg, 0.86 mmol) in 20% MeOH/CH2Cl2 (5 mL) at 0° C. was added a solution of HCl in dioxane (4 M, 1.0 mL). The reaction was warmed to RT and stirred for 16 h, then the solvents were removed under reduced pressure to afford the title compound (170 mg, 73%) as a pale yellow solid: MS (ES) m/e 273.0 (M+H)+.

Workup

  1. customthe solvents were removed under reduced pressure

Sources & evidence

ORD record
ord-89bbd8958b8541c6a0b01ed5d81e6cb8
Source dataset
uspto-grants-2010_05
Patent number
US07709496B2

Reaction notes

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