反应详情

7-(Chlorosulfonyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid (1 g) was added to ethanolamine (3 ml) in tetrahydrofuran (3 ml) and the mixture was stirred for 18 h. Hydrochloric acid was added to acidify the mixture, which was filtered to yield 1,2-dihydro-7-[[(2-hydroxyethyl)amino]sulfonyl]-1-oxo-4 isoquinolinecarboxylic acid as a white solid.

1. filtrationwas filtered