Hydrochloric Acid → HCID 59296084, compound

HRID 2233381Notes

Reaction equation

HRID 2233381 reaction equation
Cl[S:2]([C:5]1[CH:14]=[C:13]2[C:8]([C:9]([C:16]([OH:18])=[O:17])=[CH:10][NH:11][C:12]2=[O:15])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH2:19]([CH2:21][NH2:22])[OH:20].Cl>O1CCCC1>[OH:20][CH2:19][CH2:21][NH:22][S:2]([C:5]1[CH:14]=[C:13]2[C:8]([C:9]([C:16]([OH:18])=[O:17])=[CH:10][NH:11][C:12]2=[O:15])=[CH:7][CH:6]=1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 700EthanolamineHCID 59295966HCID 59295966, compound

Product 1

HCID 59296084HCID 59296084, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

7-(Chlorosulfonyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid (1 g) was added to ethanolamine (3 ml) in tetrahydrofuran (3 ml) and the mixture was stirred for 18 h. Hydrochloric acid was added to acidify the mixture, which was filtered to yield 1,2-dihydro-7-[[(2-hydroxyethyl)amino]sulfonyl]-1-oxo-4 isoquinolinecarboxylic acid as a white solid.

Workup

  1. filtrationwas filtered

Sources & evidence

ORD record
ord-ed9055cdd71244e1917487faad8996a7
Source dataset
uspto-grants-2010_05
Patent number
US07709500B2

Reaction notes

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