HCID 59295921, compound → 2-(carboxymethyl)-4-fluorobenzoic acid

HRID 2233394Notes

Reaction equation

HRID 2233394 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:17]([O:19]C)=[O:18])=[C:6]([CH:8](C(OC)=O)[C:9]([O:11]C)=[O:10])[CH:7]=1>Cl>[C:9]([CH2:8][C:6]1[CH:7]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=1[C:17]([OH:19])=[O:18])([OH:11])=[O:10]

Participants

3

Reactant 1

HCID 59295921HCID 59295921, compound

Product 1

HCID 3453952-(carboxymethyl)-4-fluorobenzoic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
110 °C

Procedure

A suspension of dimethyl [5-fluoro-2-(methoxycarbonyl)phenyl]malonate (1.80 g) in concentrated hydrochloric acid (25 ml) was heated at 110° C. for 48 h. The reaction was cooled and the subtitle compound collected as a white solid by filtration (1.0 g).

Workup

  1. temperatureThe reaction was cooled
  2. filtrationthe subtitle compound collected as a white solid by filtration (1.0 g)

Sources & evidence

ORD record
ord-2ca36af58f414a0ca311e19f37e4d677
Source dataset
uspto-grants-2010_05
Patent number
US07709500B2

Reaction notes

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