2,2-Dimethyl-1,3-dioxane-4,6-dione → Ethyl 4-(1,3-dioxoisoindolin-2-YL)-3-oxobutanoate

HRID 2233824Notes

Reaction equation

HRID 2233824 reaction equation
C[C:2]1([CH3:10])[O:7][C:6](=[O:8])[CH2:5][C:4](=[O:9])O1.[O:11]=[C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:14](=[O:21])[N:13]1[CH2:22]C(Cl)=O>>[O:11]=[C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:14](=[O:21])[N:13]1[CH2:22][C:4](=[O:9])[CH2:5][C:6]([O:7][CH2:2][CH3:10])=[O:8]

Participants

3

Reactant 2

HCID 162492,2-Dimethyl-1,3-dioxane-4,6-dioneHCID 812422H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo-

Product 1

HCID 701239Ethyl 4-(1,3-dioxoisoindolin-2-YL)-3-oxobutanoate

Procedure

The title compound was prepared in a manner analogous to Intermediate 123 starting from 2,2-dimethyl-1,3-dioxane-4,6-dione and (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl chloride.

Sources & evidence

ORD record
ord-c9ba32ba12514cc9b946a480ccc69925
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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