HCID 86608250, compound → HCID 86608251, compound

HRID 2233851Notes

Reaction equation

HRID 2233851 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][CH:11]([NH:14]C(=O)OC(C)(C)C)[CH2:10][CH2:9]2)[CH:5]=[C:4]([C:22]2[N:26]=[CH:25][O:24][N:23]=2)[CH:3]=1>Cl.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:9][CH2:10][CH:11]([NH2:14])[CH2:12][CH2:13]2)[CH:5]=[C:4]([C:22]2[N:26]=[CH:25][O:24][N:23]=2)[CH:3]=1

Participants

4

Reactant 1

HCID 86608250HCID 86608250, compound2×

Product 1

HCID 86608251HCID 86608251, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

Tert-butyl 1-[6-chloro-4-(1,2,4-oxadiazol-3-yl)pyridin-2-yl]piperidin-4-ylcarbamate (Intermediate 55) (50 mg 0.13 mmol) was dissolved in 4 N HCl in dioxane (2 ml). The mixture was stirred at room temperature for 2 h. The solvent was concentrated in vacuo to afford the crude title compound which was used without further purification. (74 mg).

Workup

  1. concentrationThe solvent was concentrated in vacuo

Sources & evidence

ORD record
ord-b4b07c71bbcc45a088430a815defeeb0
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

Loading…