O-Methylhydroxylamine hydrochloride → HCID 86608336, compound

HRID 2233994Notes

Reaction equation

HRID 2233994 reaction equation
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]2[N:23]=[C:22]([C:24]([OH:26])=O)[CH:21]=[C:20]([S:27][CH2:28][CH3:29])[N:19]=2)[CH2:14][CH2:13]1)=[O:10].Cl.[O:31]([NH2:33])[CH3:32]>>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]2[N:23]=[C:22]([C:24]([NH:33][O:31][CH3:32])=[O:26])[CH:21]=[C:20]([S:27][CH2:28][CH3:29])[N:19]=2)[CH2:14][CH2:13]1)=[O:10]

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 68579877HCID 68579877, compound

Product 1

HCID 86608336HCID 86608336, compound

Procedure

The title compound was synthesized by an analogous method to Example 8 starting from 2-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-6-(ethylthio)pyrimidine-4-carboxylic acid (Example 202) and methoxylamine hydrochloride.

Sources & evidence

ORD record
ord-5f6c0d9f984843a382c94ebdffed8586
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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