Hydrazine → HCID 86608309, compound

HRID 2234043Notes

Reaction equation

HRID 2234043 reaction equation
C(N(C(C)C)CC)(C)C.CN(C(O[N:18]1[N:26]=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C1C=NC2N(O)N=NC=2C=1.[Cl:44][C:45]1[CH:46]=[C:47]([CH:51]=[C:52]([N:54]2[CH2:59][CH2:58][CH:57]([NH:60][C:61]([C:63]3[NH:64][C:65]([CH3:70])=[C:66]([Cl:69])[C:67]=3[Cl:68])=[O:62])[CH2:56][CH2:55]2)[N:53]=1)[C:48]([OH:50])=O.NN>CN(C=O)C>[Cl:68][C:67]1[C:66]([Cl:69])=[C:65]([CH3:70])[NH:64][C:63]=1[C:61]([NH:60][CH:57]1[CH2:56][CH2:55][N:54]([C:52]2[CH:51]=[C:47]([C:48]([NH:18][NH2:26])=[O:50])[CH:46]=[C:45]([Cl:44])[N:53]=2)[CH2:59][CH2:58]1)=[O:62]

Participants

7

Reactant 5

HCID 9321HydrazineHCID 81531DiisopropylethylamineHCID 181649HOAtHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 57397809HCID 57397809, compound

Product 1

HCID 86608309HCID 86608309, compoundYield 56.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Diisopropylethylamine (0.043 ml, 0.25 mmol), HATU (0.048 g, 0.12 mmol) and HOAT (0.017 g 0.12 mmol) were added to a stirred solution of 2-chloro-6-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)isonicotinic acid (Example 153; 0.055 g, 0.12 mmol) in DMF (2 ml). The resultant solution was stirred for 5 mins and hydrazine (0.04 ml, 0.12 mmol) was added. The mixture was stirred at room temperature for 14 h, partitioned between water and EtOAc. The layers were separated and the organic layer was washed with water two more times. The organic phase was dried over magnesium sulfate and concentrated to give the title compound (30 mg).

Workup

  1. custompartitioned between water and EtOAc
  2. customThe layers were separated
  3. washthe organic layer was washed with water two more times
  4. dry with materialThe organic phase was dried over magnesium sulfate
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-d429d1d995ff49c7a8c365685292bed6
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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