Triethylamine → HCID 20522407, compound

HRID 223411Notes

Reaction equation

HRID 223411 reaction equation
[NH:1]([C:3]1[C:4](=[O:16])[N:5]([CH3:15])[C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([O:13][CH3:14])=[CH:8][CH:7]=2)[NH2:2].C(N(CC)CC)C.[CH3:24][CH:25]([CH3:29])[C:26](Cl)=[O:27]>O1CCOCC1>[CH3:15][N:5]1[C:6]2[C:11](=[CH:10][C:9]([O:13][CH3:14])=[CH:8][CH:7]=2)[N:12]=[C:3]([NH:1][NH:2][C:26](=[O:27])[CH:25]([CH3:29])[CH3:24])[C:4]1=[O:16]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 62325Isobutyryl chlorideHCID 20522402HCID 20522402, compound

Product 1

HCID 20522407HCID 20522407, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 3-hydrazino-1-methyl-6-methoxy-1H-quinoxalin-2-one (46.2 mmol) and triethylamine (5.6 g., 55.4 mmol) in 500 ml. of dioxane was added dropwise 2-methylpropanoyl chloride (5.91 g., 55.4 mmol) and the mixture stirred at room temperature for 1.5 hours. The dioxane was then removed under vacuum and the residue washed with water and ether, filtered, and dried at 65° for three hours to yield crude product.

Workup

  1. customThe dioxane was then removed under vacuum
  2. washthe residue washed with water and ether
  3. filtrationfiltered
  4. customdried at 65° for three hours
  5. customto yield crude product

Sources & evidence

ORD record
ord-e851d4ab8e104375b1406b7f42983171
Source dataset
uspto-grants-1982_10
Patent number
US04354027

Reaction notes

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