Hydrogen Bromide → AZD-3199 dihydrobromide

HRID 2234192Notes

Reaction equation

HRID 2234192 reaction equation
[CH2:1]([N:3]([CH2:40][CH3:41])[CH2:4][CH2:5][N:6]([CH2:24][CH2:25][NH:26][CH2:27][CH2:28][C:29]1[C:37]2[S:36][C:35](=[O:38])[NH:34][C:33]=2[C:32]([OH:39])=[CH:31][CH:30]=1)[C:7](=[O:23])[CH2:8][CH2:9][O:10][CH2:11][CH2:12][C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1)[CH3:2].[BrH:42]>C(O)C>[BrH:42].[BrH:42].[CH2:40]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][N:6]([CH2:24][CH2:25][NH:26][CH2:27][CH2:28][C:29]1[C:37]2[S:36][C:35](=[O:38])[NH:34][C:33]=2[C:32]([OH:39])=[CH:31][CH:30]=1)[C:7](=[O:23])[CH2:8][CH2:9][O:10][CH2:11][CH2:12][C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1)[CH3:41]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 16035068Azd-3199

Product 1

HCID 25031637AZD-3199 dihydrobromide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-[2-(Diethylamino)ethyl]-N-(2-{[2-(4-hydroxy-2-oxo-2,3-dihydro-1,3-benzothiazol-7-yl)ethyl]amino}ethyl)-3-[2-(1-naphthyl)ethoxy]propanamide prepared as described in Example 7 (52 mg) was dissolved in ethanol (1.5 ml) and treated with 48% hydrobromic acid (21 μl). The white solid dihydrobromide salt was collected by filtration. Yield 58 mg.

Workup

  1. filtrationThe white solid dihydrobromide salt was collected by filtration

Sources & evidence

ORD record
ord-a0a8a0c0fe8742d388cf43fd83a924dc
Source dataset
uspto-grants-2010_05
Patent number
US07709511B2

Reaction notes

Loading…