Pyrrolidine → tert-butyl N-(4-pyrrolidin-1-ylcyclohexyl)carbamate

HRID 2234501Notes

Reaction equation

HRID 2234501 reaction equation
[N:1]1([CH:5]2[CH2:10][CH2:9][CH:8]([NH:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.N1CCC[CH2:20]1>>[N:1]1([CH:5]2[CH2:10][CH2:9][CH:8]([NH:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])[CH2:7][CH2:6]2)[CH2:20][CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 68684591tert-butyl N-[4-(azetidin-1-yl)cyclohexyl]carbamate

Product 1

HCID 21882609tert-butyl N-(4-pyrrolidin-1-ylcyclohexyl)carbamate

Procedure

The title compound was prepared by an analogous method to the preparation of Intermediate 227, on a 2.34 mmol scale utilising pyrrolidine (Aldrich; 250 μL, 3.04 mmol), as a white solid (175 mg, 44%).

Sources & evidence

ORD record
ord-e608af0bf27c42a48f8f6bbb403948c9
Source dataset
uspto-grants-2010_05
Patent number
US07709471B2

Reaction notes

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