Methyl Acrylate → HCID 11458109, compound

HRID 2234517Notes

Reaction equation

HRID 2234517 reaction equation
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:8]([O:12][CH3:13])(=[O:11])[CH:9]=[CH2:10]>C1COCC1>[CH3:13][O:12][C:8](=[O:11])[CH2:9][CH2:10][NH:7][CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 7294Methyl AcrylateHCID 7965Cyclohexylamine

Product 1

HCID 11458109HCID 11458109, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Cyclohexylamine (Aldrich; 17 g, 0.174 mol) was dissolved in THF (300 mL). To this was added methyl acrylate (Aldrich; 15 g, 0.174 mol) in one portion. The reaction mixture was stirred over the weekend. The solvent was evaporated with care due to the volatility of the product and the residue distilled at 72° C. at 0.30 mbar to yield the title compound as a clear oil (23.7 g, 74%).

Workup

  1. customThe solvent was evaporated with care due to the volatility of the product
  2. distillationthe residue distilled at 72° C. at 0.30 mbar

Sources & evidence

ORD record
ord-781b5ddda03e490f84936c189db3bc94
Source dataset
uspto-grants-2010_05
Patent number
US07709471B2

Reaction notes

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