反应详情

温度

-20 °C

A solution of m-chloroperbenzoic acid (14.3 g, 1.2 eq) in 100 ml of dichloromethane was added drop wise to the solution of 13 (17.3 g) in 150 ml of dichloromethane at −20° C. The temperature was maintained at −20° C. for an additional 40 minutes. A saturated solution of sodium bicarbonate (80 ml) was added and stirred for 30 minutes. The organic layer was separated and washed with brine (50 ml) and dried over sodium sulfate. After purification (via a column) 13.4 g of the desired product (as a heavy oil) was obtained.

1. customThe organic layer was separated
2. washwashed with brine (50 ml)
3. dry with materialdried over sodium sulfate
4. customAfter purification (via a column) 13.4 g of the desired product (as a heavy oil)
5. customwas obtained