反应详情

A solution of 4-[cis-3,5-dimethyl-1-piperazinyl]-N-(diphenylmethylidene)-2-pyridinamine (D20) (650 mg, 1.76 mmol) in tetrahydrofuran (5 ml) was treated with 1.0M hydrochloric acid (5 ml) and the mixture stirred at room temperature for 1 hour. The mixture was diluted with water and washed with diethyl ether. The aqueous phase was basified with 50% aq. sodium hydroxide then saturated with sodium chloride. The mixture was extracted with ethyl acetate (×2). The combined extracts were dried and evaporated to give the title compound (D21). 1H NMR CDCl3 ppm δ (6H, d), 2.33-0.238 (2H, m), 2.91-2.96 (2H, m), 3.58-3.62 (2H, m), 5.85 (1H, s), 6.18-6.20 (1H, m), 7.78-8.00 (1H, d).

1. washwashed with diethyl ether
2. extractionThe mixture was extracted with ethyl acetate (×2)
3. customThe combined extracts were dried
4. customevaporated