反应详情

A solution of ethyl 5-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-3-pyridinecarboxylate (D32) (800 mg, 3 mmol) in tetrahydrofuran (5 ml) was treated with 0.5M lithium hydroxide (12 ml, 6 mmol). The mixture was stirred at room temperature for 2 hours. The reaction was quenched with acetic acid (1 ml). The solvent was evaporated and the residue purified on SCX eluting with 2M ammonia in methanol to give the title compound (D33). MS (ES+) m/e 236 [M+H]+.

1. customThe reaction was quenched with acetic acid (1 ml)
2. customThe solvent was evaporated
3. customthe residue purified on SCX
4. washeluting with 2M ammonia in methanol