Ethyl formate → HCID 11659015, compound

HRID 2235007Notes

Reaction equation

HRID 2235007 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH:9]2[CH2:15][CH:14]3[NH:16][CH:11]([CH2:12][CH2:13]3)[CH2:10]2)=[N:6][CH:7]=1.[CH:17](OCC)=[O:18]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH:9]2[CH2:15][CH:14]3[N:16]([CH:17]=[O:18])[CH:11]([CH2:12][CH2:13]3)[CH2:10]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 11447790HCID 11447790, compound

Product 1

HCID 11659015HCID 11659015, compound

Procedure

To 10 ml of ethyl format was added 0.4 g of 3-(5-Chloro-pyridin-2-yloxy)-8-aza-bicyclo[3.2.1]octane, the mixture was heated at reflux for 48 hours and evaporated to dryness, crystallized from ethyl acetate petroleum ether. Yield 200 mg (53%), Mp. 112-114° C.

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 48 hours
  3. customevaporated to dryness
  4. customcrystallized from ethyl acetate petroleum ether

Sources & evidence

ORD record
ord-bd980439e6e74067a6b0b7bd2da523e6
Source dataset
uspto-grants-2010_05
Patent number
US07713990B2

Reaction notes

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