1,1-Dimethyl-2-(2-phenoxyacetamido)ethylamine → Hydrochloric Acid

HRID 223502Notes

Reaction equation

HRID 223502 reaction equation
[CH3:1][C:2]([NH2:16])([CH3:15])[CH2:3][NH:4][C:5](=[O:14])[CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.O.[NH2:18][C:19]1[C:24]([Cl:25])=[CH:23][C:22]([C:26]([CH:28]=O)=[O:27])=[CH:21][C:20]=1[Cl:30]>>[NH2:18][C:19]1[C:20]([Cl:30])=[CH:21][C:22]([CH:26]([OH:27])[CH2:28][NH:16][C:2]([CH3:1])([CH3:15])[CH2:3][NH:4][C:5](=[O:14])[CH2:6][O:7][C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:23][C:24]=1[Cl:25].[ClH:25]

Participants

4

Reactant 2

HCID 118062741,1-Dimethyl-2-(2-phenoxyacetamido)ethylamineHCID 205215294-Amino-3,5-dichlorophenylglyoxal hydrate

Product 2

HCID 313Hydrochloric AcidHCID 540867411-(4-Amino-3,5-dichlorophenyl)-2-[1,1-dimethyl-2-(2-phenoxyacetamido)ethylamino]ethanol

Procedure

In a similar manner but using 1,1-dimethyl-2-(2-phenoxyacetamido)ethylamine and 4-amino-3,5-dichlorophenylglyoxal hydrate as starting materials there was obtained 1-(4-amino-3,5-dichlorophenyl)-2-[1,1-dimethyl-2-(2-phenoxyacetamido)ethylamino]ethanol (Example 2) in 35% yield, m.p. 107°-9° C. (hydrochloride, monohydrate).

Sources & evidence

ORD record
ord-0d2c274e2e0d46bcac9c31c8b7e52d6f
Source dataset
uspto-grants-1982_10
Patent number
US04355045

Reaction notes

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