反应详情

1.45 g of 4-acetylamino-2-methyl-benzenesulphonyl chloride (5.85 mmol) at 0° C. are suspended in 19 ml sodium hydroxide solution (1 M) and then 0.51 ml pyrrolidine (6.47 mmol), dissolved in 9 ml acetone, are added dropwise within half an hour. The solution is heated to ambient temperature overnight and then acidified with hydrochloric acid (2 M). The suspension is extracted twice with ethyl acetate. The combined organic phases are dried over sodium sulphate and evaporated down. A brown oil remains.

1. customat 0° C.
2. additionare added dropwise within half an hour
3. extractionThe suspension is extracted twice with ethyl acetate
4. dry with materialThe combined organic phases are dried over sodium sulphate
5. customevaporated down