Water → HCID 136110688, compound

HRID 223509Notes

Reaction equation

HRID 223509 reaction equation
[CH2:1]([N:8]1[C:12]([CH2:13][C:14]([OH:16])=[O:15])=[C:11]([Cl:17])[N:10]=[C:9]1[C:18]1[CH:23]=[CH:22][C:21]([O:24]CCCC)=[CH:20][CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O>Br>[CH2:1]([N:8]1[C:12]([CH2:13][C:14]([OH:16])=[O:15])=[C:11]([Cl:17])[N:10]=[C:9]1[C:18]1[CH:19]=[CH:20][C:21]([OH:24])=[CH:22][CH:23]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 962WaterHCID 15099415HCID 15099415, compound

Product 1

HCID 136110688HCID 136110688, compoundYield 58.2%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

1 g of 1-benzyl-4-chloro-2-(4-n-butoxyphenyl)imidazole-5-acetic acid was boiled in 14 ml of 48% hydrobromic acid for 2 hours, and addition of 15 ml of water, followed by allowing the solution to stand, resulted in crystals deposited. Recrystallization of the crystals from aqueous ethanol yielded 0.5 g of 1-benzyl-4-chloro-2-(4-hydroxyphenyl)imidazole-5-acetic acid as colorless, prism-formed crystals, m.p. 140°-145° C.

Workup

  1. customresulted in crystals
  2. customRecrystallization of the crystals from aqueous ethanol

Sources & evidence

ORD record
ord-c159ab0cc04d4353af17c5a4f775b1e2
Source dataset
uspto-grants-1982_10
Patent number
US04355040

Reaction notes

Loading…