反应详情

Add 1M LAH in THF (20 mL, 20 mmol) to 3-bromo-6-chloro-2-fluoro-benzaldehyde (Preparation 7) (4.9 g, 20 mmol) in THF (20 mL) at −78° C. Stir for 15 minutes and warm up to room temperature. Add reaction mixture into ice and water. Add 1M HCl (5 mL, 5 mmol) to dissolve the solid. Extract the mixture with ethyl acetate (50 mL), dry with magnesium sulfate, filter and evaporate solvent under reduced pressure to obtain 4.6 g (94%) of the title compound as a white solid.

1. additionAdd
2. dissolutionto dissolve the solid
3. extractionExtract the mixture with ethyl acetate (50 mL)
4. dry with materialdry with magnesium sulfate
5. filtrationfilter
6. customevaporate solvent under reduced pressure