Gamma-Butyrolactone → HCID 59299396, compound

HRID 2235190Notes

Reaction equation

HRID 2235190 reaction equation
[C:1]1(=[O:6])[O:5][CH2:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:9]=1[CH2:10]I>>[Cl:7][C:8]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:9]=1[CH2:10][CH:2]1[CH2:3][CH2:4][O:5][C:1]1=[O:6]

Participants

3

Reactant 2

HCID 7302Gamma-ButyrolactoneHCID 5183222,4-DICHLOROBENZYL IODIDE

Product 1

HCID 59299396HCID 59299396, compoundYield 78.5%

Procedure

Using the procedure to synthesize Example 1 and using reagents γ-butyrolactone (1.1 g, 13 mmol), and 2,4-dichlorobenzyl iodide (5.6 g, 20 mmol) affords 2.5 g (78%) of the title compound as a tan solid. 1H NMR (CDCl3) δ 7.36 (d, 1H), 7.17 (m, 2H), 4.30 (m, 1H), 4.10 (m, 1H), 3.32 (dd, 1H), 2.87-2.78 (m, 2H), 2.20 (m, 1H), 1.95 (m, 1H).

Workup

  1. customto synthesize Example 1

Sources & evidence

ORD record
ord-014d1e9a81fe46488a999432228cf899
Source dataset
uspto-grants-2010_05
Patent number
US07713979B2

Reaction notes

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