反应详情

温度

0 °C

Dissolve (2,6-dichloro-4-trifluoromethyl-phenyl)-methanol (7.5 g, 31 mmol) is THF (40 mL) and cool to 0° C. Add PBr3 (5.0 g, 18 mmol) under nitrogen and stir at 0° C. for 30 minutes. Pour into saturated aqueous sodium bicarbonate and extract with methylene chloride. Dry over sodium sulfate, filter and concentrate. Purify over silica gel (hexanes) to obtain 9.0 g (96%) of the title compound.

1. extractionextract with methylene chloride
2. dry with materialDry over sodium sulfate
3. filtrationfilter
4. concentrationconcentrate
5. customPurify over silica gel (hexanes)