反应详情

Dissolve 2,6-dichloro-3-hydroxy-benzaldehyde (10.7 g, 56 mmol) in N,N-dimethylformamide (80 ml), add potassium carbonate (15 g, 112 mmol), cesium carbonate(18.3 g, 56 mmol), iodomethane (7 ml, 112 mmol) and stir over night at room temperature. Filter reaction mixture into water washing solids with DMF, extract filtrate with ethyl acetate wash with water, brine, dry over sodium sulfate, filter and concentrate to yield 10 g (87%) of 2,6-dichloro-3-methoxy-benzaldehyde.

1. filtrationFilter
2. customreaction mixture into water washing solids with DMF
3. extractionextract filtrate with ethyl acetate
4. washwash with water, brine
5. dry with materialdry over sodium sulfate
6. filtrationfilter
7. concentrationconcentrate