反应详情

Add 1-[cis-4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-3-(2,6-dichloro-4-hydroxy-benzyl)-pyrrolidin-2-one (Preparation 72) (0.543 g, 1.15 mmol), 2-bromopropane (0.212 g, 1.72 mmol), and potassium carbonate (0.365 g, 2.64 mmol) together with acetone (10 mL) and reflux overnight. Concentrate the reaction mixture under reduced pressure to give a residue. Purify the residue over silica gel, (98:2 dichloromethane in methanol) to give 0.080 g (14%) of the title compound: mass spectrum m/z: 516(M+1).

1. temperaturereflux overnight
2. concentrationConcentrate the reaction mixture under reduced pressure
3. customto give a residue
4. customPurify the residue over silica gel, (98:2 dichloromethane in methanol)