Hydrochloric Acid → HCID 178479619, compound

HRID 2235319Notes

Reaction equation

Cl.C([Si](C)(C)[O:7][C@@H:8]1[CH2:13][CH2:12][C@H:11]([N:14]2[CH2:18][CH2:17][CH:16]([CH2:19][C:20]3[C:25]([Cl:26])=[CH:24][C:23]([C:27]4[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=4)=[CH:22][C:21]=3[Cl:33])[C:15]2=[O:34])[CH2:10][CH2:9]1)(C)(C)C>CO>[ClH:26].[Cl:33][C:21]1[CH:22]=[C:23]([C:27]2[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=2)[CH:24]=[C:25]([Cl:26])[C:20]=1[CH2:19][CH:16]1[CH2:17][CH2:18][N:14]([C@H:11]2[CH2:12][CH2:13][C@@H:8]([OH:7])[CH2:9][CH2:10]2)[C:15]1=[O:34]

Participants

Conditions

Temperature: 40 °C

Procedure

Add HCl (0.015 mL) to 1-[cis-4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-3-(2,6-dichloro-4-pyridin-3-yl-benzyl)-pyrrolidin-2-one (Preparation 75) (0.027 G, 0.0506 mmol) in methanol (2 mL) and heat to 40° C. for 1 hour. Concentrate under reduced pressure to give the title compound (0.017 g): mass spectrum (m/z):420(M+1).

Workup

concentrationConcentrate under reduced pressure

Sources & evidence

ORD record: ord-7aa50012cc1b4622afb0ab9d78b7c9f9
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07713979B2

Reaction notes

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