Tetrahydrofuran → N-(3,3-Dimethyl-6-nitro-2-oxo-1-pent-2-ynyl-2,3-dihydro-1H-indol-5-yl)-3-phenyl-propionamide

HRID 2235402Notes

Reaction equation

HRID 2235402 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[N:7]([CH2:14][C:15]#[C:16][CH2:17][CH3:18])[C:6](=[O:19])[C:5]2([CH3:21])[CH3:20].[CH2:22]1[CH2:26][O:25][CH2:24][CH2:23]1>>[CH3:21][C:5]1([CH3:20])[C:4]2[C:8](=[CH:9][C:10]([N+:11]([O-:13])=[O:12])=[C:2]([NH:1][C:24](=[O:25])[CH2:23][CH2:22][C:26]3[CH:4]=[CH:3][CH:2]=[CH:10][CH:9]=3)[CH:3]=2)[N:7]([CH2:14][C:15]#[C:16][CH2:17][CH3:18])[C:6]1=[O:19]

Participants

3

Reactant 2

HCID 8028TetrahydrofuranHCID 593009855-Amino-3,3-dimethyl-6-nitro-1-(pent-2-ynyl)-1,3-dihydro-indol-2-one

Product 1

HCID 67427209N-(3,3-Dimethyl-6-nitro-2-oxo-1-pent-2-ynyl-2,3-dihydro-1H-indol-5-yl)-3-phenyl-propionamide

Procedure

N-(3,3-Dimethyl-6-nitro-2-oxo-1-pent-2-ynyl-2,3-dihydro-1H-indol-5-yl)-3-phenyl-propionamide is prepared as described in Example 25a starting from A7 (73 mg) using THF (3 ml) as solvent. The crude material (106 mg) is used without further purification.

Workup

  1. customThe crude material (106 mg) is used without further purification

Sources & evidence

ORD record
ord-41c4b5ce1c1147e7941f9fdc4c58253e
Source dataset
uspto-grants-2010_05
Patent number
US07714010B2

Reaction notes

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