Iodoethane → HCID 59300846, compound

HRID 2235416Notes

Reaction equation

HRID 2235416 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-])=O)[N:7]([CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:6](=[O:19])[C:5]2([CH3:21])[CH3:20].[C:22]1([CH2:28][CH2:29][CH2:30][C:31](Cl)=O)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[CH2:34](I)[CH3:35]>>[CH2:34]([N:1]1[C:2]2=[CH:3][C:4]3[C:5]([CH3:21])([CH3:20])[C:6](=[O:19])[N:7]([CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:8]=3[CH:9]=[C:10]2[N:11]=[C:31]1[CH2:30][CH2:29][CH2:28][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[CH3:35]

Participants

4

Reactant 3

HCID 6340IodoethaneHCID 117898654-Phenylbutanoyl ChlorideHCID 178027445-Amino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-one

Product 1

HCID 59300846HCID 59300846, compoundYield 12.6%

Procedure

1-Ethyl-7,7-dimethyl-5-pentyl-2-(3-phenyl-propyl)-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one (36 mg) is synthesized from A8 (200 mg), freshly prepared 4-phenyl-butyryl chloride (150 mg; 0.82 mmol) and ethyl iodide (70 μl; 0.87 mmol) as described in Example 57.

Sources & evidence

ORD record
ord-06e02ba3d80440348347200b14d986fc
Source dataset
uspto-grants-2010_05
Patent number
US07714010B2

Reaction notes

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