HCID 23092668, compound → HCID 17802736, compound

HRID 2235422Notes

Reaction equation

HRID 2235422 reaction equation
[CH3:1][N:2]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][C:14]=1[N+:15]([O-:17])=[O:16])[N:11]([CH3:18])[C:10](=[O:19])[C:9]2([CH3:21])[CH3:20])C(=O)C>Cl>[CH3:18][N:11]1[C:12]2[C:8](=[CH:7][C:6]([NH:2][CH3:1])=[C:14]([N+:15]([O-:17])=[O:16])[CH:13]=2)[C:9]([CH3:20])([CH3:21])[C:10]1=[O:19]

Participants

3

Reactant 1

HCID 23092668HCID 23092668, compound

Product 1

HCID 17802736HCID 17802736, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

The crude N-methyl-N-(1,3,3-trimethyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)-acetamide is dissolved in hydrochloric acid (6 N; 8 ml) and heated at reflux for 3 h. The mixture is poured into ice-water and the resulting precipitate collected by filtration. After drying the compound (176 mg) is obtained.

Workup

  1. temperatureheated
  2. temperatureat reflux for 3 h
  3. filtrationthe resulting precipitate collected by filtration
  4. dry with materialAfter drying the compound (176 mg)
  5. customis obtained

Sources & evidence

ORD record
ord-7605ede9eaab4354a8aab33f818ccb7c
Source dataset
uspto-grants-2010_05
Patent number
US07714010B2

Reaction notes

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