Hydrochloric Acid → HCID 59301006, compound

HRID 2235427Notes

Reaction equation

HRID 2235427 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:16]1[NH:35][C:19]2=[CH:20][C:21]3[C:22]([CH3:34])([CH3:33])[C:23](=[O:32])[N:24]([CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[C:25]=3[CH:26]=[C:18]2[N:17]=1)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(C)(C)C.Cl>O1CCOCC1>[NH2:7][C@H:8]([C:16]1[NH:35][C:19]2=[CH:20][C:21]3[C:22]([CH3:34])([CH3:33])[C:23](=[O:32])[N:24]([CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[C:25]=3[CH:26]=[C:18]2[N:17]=1)[CH2:9][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131728116HCID 131728116, compound

Product 1

HCID 59301006HCID 59301006, compoundYield 108%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

[(S)-1-(7,7-Dimethyl-6-oxo-5-pentyl-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester (50 mg) is treated with a mixture of 1,4-dioxane (5 ml) and hydrochloric acid (2 N; 5 ml) for 15 min at 50° C. The solvents are evaporated and the residue lyophilized. The desired compound (43 mg) is obtained as a hydrochloride (white solid).

Workup

  1. customThe solvents are evaporated

Sources & evidence

ORD record
ord-cc23b85839a94086ad8cd9f86777e708
Source dataset
uspto-grants-2010_05
Patent number
US07714010B2

Reaction notes

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