Triethylamine → HCID 86601808, compound

HRID 2235448Notes

Reaction equation

HRID 2235448 reaction equation
[CH3:1][C:2]1([CH3:26])[C:10]2[C:5](=[CH:6][C:7]([N+:22]([O-:24])=[O:23])=[C:8]([NH:11][C:12](=[O:21])[C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)[CH:9]=2)[NH:4][C:3]1=[O:25].Cl[C:28]([O:30][C:31]1[CH:36]=[CH:35][C:34]([N+:37]([O-:39])=[O:38])=[CH:33][CH:32]=1)=[O:29].CCN(CC)CC>C1(C)C=CC=CC=1>[N+:37]([C:34]1[CH:33]=[CH:32][C:31]([O:30][C:28]([N:4]2[C:5]3[C:10](=[CH:9][C:8]([NH:11][C:12](=[O:21])[C:13]4[CH:14]=[CH:15][C:16]([O:19][CH3:20])=[CH:17][CH:18]=4)=[C:7]([N+:22]([O-:24])=[O:23])[CH:6]=3)[C:2]([CH3:26])([CH3:1])[C:3]2=[O:25])=[O:29])=[CH:36][CH:35]=1)([O-:39])=[O:38]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 821294-Nitrophenyl chloroformateHCID 23092680HCID 23092680, compound

Product 1

HCID 86601808HCID 86601808, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of N-(3,3-dimethyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)4-methoxy-benzamide (200 mg), 4-nitrophenyl chloroformate (166 mg; 0.83 mmol) and NEt3 (0.2 ml) in dry toluene (3 ml) is stirred in a microwave apparatus at 150° C. for 800 s. The resulting precipitate is collected by filtration and washed with cold toluene. After drying under reduced pressure the compound (240 mg) is obtained.

Workup

  1. filtrationThe resulting precipitate is collected by filtration
  2. washwashed with cold toluene
  3. dry with materialAfter drying under reduced pressure the compound (240 mg)
  4. customis obtained

Sources & evidence

ORD record
ord-a34f1d9c755c4e72818f569f48301a9d
Source dataset
uspto-grants-2010_05
Patent number
US07714010B2

Reaction notes

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