HRID2235448

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID82129

Carbonochloridic acid, 4-nitrophenyl ester

C7H4ClNO4

结构：COc1ccc(C(=O)Nc2cc3c(cc2[N+](=O)[O-])NC(=O)C3(C)C)cc1

HCID23092680

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C(=O)Nc2cc3c(cc2[N+](=O)[O-])N(C(=O)Oc2ccc([N+](=O)[O-])cc2)C(=O)C3(C)C)cc1

HCID86601808

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

A solution of N-(3,3-dimethyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)4-methoxy-benzamide (200 mg), 4-nitrophenyl chloroformate (166 mg; 0.83 mmol) and NEt3 (0.2 ml) in dry toluene (3 ml) is stirred in a microwave apparatus at 150° C. for 800 s. The resulting precipitate is collected by filtration and washed with cold toluene. After drying under reduced pressure the compound (240 mg) is obtained.

WORKUP

后处理

filtrationThe resulting precipitate is collected by filtration
washwashed with cold toluene
dry with materialAfter drying under reduced pressure the compound (240 mg)
customis obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a34f1d9c755c4e72818f569f48301a9d
来源数据集: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07714010B2
来源说明: uspto-grants-2010_05

反应 SMILES

[CH3:1][C:2]1([CH3:26])[C:10]2[C:5](=[CH:6][C:7]([N+:22]([O-:24])=[O:23])=[C:8]([NH:11][C:12](=[O:21])[C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)[CH:9]=2)[NH:4][C:3]1=[O:25].Cl[C:28]([O:30][C:31]1[CH:36]=[CH:35][C:34]([N+:37]([O-:39])=[O:38])=[CH:33][CH:32]=1)=[O:29].CCN(CC)CC>C1(C)C=CC=CC=1>[N+:37]([C:34]1[CH:33]=[CH:32][C:31]([O:30][C:28]([N:4]2[C:5]3[C:10](=[CH:9][C:8]([NH:11][C:12](=[O:21])[C:13]4[CH:14]=[CH:15][C:16]([O:19][CH3:20])=[CH:17][CH:18]=4)=[C:7]([N+:22]([O-:24])=[O:23])[CH:6]=3)[C:2]([CH3:26])([CH3:1])[C:3]2=[O:25])=[O:29])=[CH:36][CH:35]=1)([O-:39])=[O:38]