Stannous chloride dihydrate → HCID 67426573, compound

HRID 2235451Notes

Reaction equation

HRID 2235451 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([N+:11]([O-])=O)=[CH:8][CH:9]=2)[C:4]2([CH2:15][CH2:14]2)[C:3]1=[O:16].O.O.Cl[Sn]Cl>CCOC(C)=O>[NH2:11][C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[N:2]([CH3:1])[C:3](=[O:16])[C:4]12[CH2:14][CH2:15]1

Participants

4

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 67426568HCID 67426568, compound

Product 1

HCID 67426573HCID 67426573, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1′-Methyl-5′-nitro-spiro[cyclopropane-1,3′-indoline]-2′-one (3 g) is dissolved in EtOAc (105 ml) and SnCl2.2H2O (9 g; 46.5 mmol) is added. The reaction mixture is refluxed overnight, cooled and filtered over Al2O3. After an aqueous work-up of the filtrate the compound (2.2 g) is obtained.

Workup

  1. temperatureThe reaction mixture is refluxed overnight
  2. temperaturecooled
  3. filtrationfiltered over Al2O3

Sources & evidence

ORD record
ord-66ee32ff88f9467e8c15007945d8af2f
Source dataset
uspto-grants-2010_05
Patent number
US07714010B2

Reaction notes

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