Water → HCID 67425846, compound

HRID 2235453Notes

Reaction equation

HRID 2235453 reaction equation
FC(F)(F)C([NH:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][C:14]=1[N+:15]([O-:17])=[O:16])[N:11]([CH3:18])[C:10](=[O:19])[C:9]12[CH2:21][CH2:20]1)=O.CN(C=O)C.O.C([O-])([O-])=O.[K+].[K+]>CO>[NH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][C:14]=1[N+:15]([O-:17])=[O:16])[N:11]([CH3:18])[C:10](=[O:19])[C:9]12[CH2:20][CH2:21]1

Participants

6

Reactant 4

HCID 962Water2×HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 86601810HCID 86601810, compound

Product 1

HCID 67425846HCID 67425846, compoundYield 70.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

2,2,2-Trifluoro-N-(1′-methyl-6′-nitro-2′-oxo-spiro[cyclopropane-1,3′-indole]-5′-yl)-acetamide (2 g) is dissolved in MeOH (15 ml), DMF (10 ml) and water (6.1 ml). Freshly powdered K2CO3 (2.9 g; 21 mmol) is added and the reaction is stirred at 50° C. for 12 h. After completion of the reaction the mixture is poured into water and the precipitate is collected by filtration and washed with 2-propanol and tertbutylmethyl ether. The compound (1 g) is obtained as a red solid.

Workup

  1. customAfter completion of the reaction the mixture
  2. filtrationthe precipitate is collected by filtration
  3. washwashed with 2-propanol and tertbutylmethyl ether

Sources & evidence

ORD record
ord-9d4f9145bf0d4c8e83db47586b5be357
Source dataset
uspto-grants-2010_05
Patent number
US07714010B2

Reaction notes

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