HCID 67425846, compound → HCID 67427197, compound

HRID 2235454Notes

Reaction equation

HRID 2235454 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-])=O)[N:7]([CH3:14])[C:6](=[O:15])[C:5]12[CH2:17][CH2:16]1>CO.Cl.[Pd]>[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[NH2:11])[N:7]([CH3:14])[C:6](=[O:15])[C:5]12[CH2:16][CH2:17]1

Participants

5

Reactant 1

HCID 67425846HCID 67425846, compound

Product 1

HCID 67427197HCID 67427197, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

Analogously to general procedure (II) the compound is prepared from 5′-amino-1′-methyl-6′-nitro-spiro[cyclopropane-1,3′-indoline]-2′-one (50 mg) in MeOH (10 ml) and hydrochloric acid (1 ml) using Pd/C (15.0 mg) as catalyst (3 h; 1 bar). After an aqueous work-up the compound is used without further purification.

Workup

  1. custom(3 h; 1 bar)
  2. customAfter an aqueous work-up the compound is used without further purification

Sources & evidence

ORD record
ord-a717549f3e4c4e06a0c8b3a84bc6b685
Source dataset
uspto-grants-2010_05
Patent number
US07714010B2

Reaction notes

Loading…