反应详情

温度

85 °C

A mixture of 0.52 g (2.4 mmol) of 2-chloro-N4,N4-dipropylpyridin-4-amine, 0.076 g (0.12 mmol) of racemic 2,2′-bis(diphenylphosphino)-1,1′-binaphtyl (BINAP), 0.33 g (3.4 mmol) of sodium tert-butoxide and 0.027 g (0.12 mmol) of palladium (II) acetate in 25 mL of toluene was treated with 0.49 mL (2.9 mmol) of benzophenone imine and heated to 85° C. for 18 h. The crude reaction mixture was diluted with ethyl acetate, filtered through a pad of celite and purified by flash chromatography eluting with a 33% hexanes/ethyl acetate mixture to give 0.65 g (75%) of the title compound as a golden oil.

1. customThe crude reaction mixture
2. filtrationfiltered through a pad of celite
3. custompurified by flash chromatography
4. washeluting with a 33% hexanes/ethyl acetate mixture