反应详情

To 0.165 g (0.55 mmol) of 7-nitro-N-(1-phenylethyl)-1,3-benzothiazol-2-amine in 10 mL of DMF was added 0.62 g (2.8 mmol) of stannous chloride dihydrate. The reaction was heated to 80° C. for 48 h and neutralized with saturated sodium bicarbonate. The mixture was filtered through celite and extracted with ethyl acetate. The extracts were dried in vacuo and purified by flash chromatography eluting with a 50-75% ethyl acetate/hexanes gradient mixture to give 0.016 g (11%) of the title compound as a light yellow solid.

1. filtrationThe mixture was filtered through celite
2. extractionextracted with ethyl acetate
3. customThe extracts were dried in vacuo
4. custompurified by flash chromatography
5. washeluting with a 50-75% ethyl acetate/hexanes gradient mixture