反应详情

To a solution of 2.80 g (22.7 mmol) of N3-methylpyridine-3,4-diamine in 125 mL of THF was added 4.42 g (27.3 mmol) of 1,1′-carbonyldiimidazole and the reaction was stirred overnight at room temperature. The reaction slurry was concentrated in vacuo to a volume of about 65 mL and cooled in a −10° C. bath, filtered, and the solids washed with 25 mL of THF. The solids were dried under high vacuum to give 2.35 g (69%) of the title compound.

1. concentrationThe reaction slurry was concentrated in vacuo to a volume of about 65 mL
2. temperaturecooled in a −10° C. bath
3. filtrationfiltered
4. washthe solids washed with 25 mL of THF
5. customThe solids were dried under high vacuum