Hydrochloric Acid → HCID 67067375, compound

HRID 2235703Notes

Reaction equation

HRID 2235703 reaction equation
Cl.[Cl:2][CH2:3][CH2:4][CH2:5][CH:6]([C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=1)[C:7]([NH:9][NH:10]C(OC(C)(C)C)=O)=[O:8]>C(OCC)(=O)C>[ClH:2].[Cl:2][CH2:3][CH2:4][CH2:5][CH:6]([C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=1)[C:7]([NH:9][NH2:10])=[O:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67067215HCID 67067215, compound

Product 1

HCID 67067375HCID 67067375, compoundYield 162.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A solution of 4 N hydrochloric acid in ethyl acetate (2 mL) was added to a solution of tert-butyl N′-[5-chloro-2-(4-fluorophenyl)pentanoyl]hydrazinecarboxylate (517 mg) in ethyl acetate (2 mL), and the reaction solution was stirred at room temperature for four hours. The reaction solution was concentrated under reduced pressure to obtain 342 mg of the title compound. The property values of the compound are as follows.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-5565355af00d4cac8ff39c2a01b77d37
Source dataset
uspto-grants-2010_05
Patent number
US07713993B2

Reaction notes

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