Hydrochloric Acid → 1-Amino-3-(3,4,5-trifluorophenyl)piperidin-2-one hydrochloride

HRID 2235708Notes

Reaction equation

HRID 2235708 reaction equation
[ClH:1].C(OC(=O)[NH:8][N:9]1[CH2:14][CH2:13][CH2:12][CH:11]([C:15]2[CH:20]=[C:19]([F:21])[C:18]([F:22])=[C:17]([F:23])[CH:16]=2)[C:10]1=[O:24])(C)(C)C>C(OCC)(=O)C.C(Cl)(Cl)Cl>[ClH:1].[NH2:8][N:9]1[CH2:14][CH2:13][CH2:12][CH:11]([C:15]2[CH:16]=[C:17]([F:23])[C:18]([F:22])=[C:19]([F:21])[CH:20]=2)[C:10]1=[O:24]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86628505Tert-butyl[2-oxo-3-(3,4,5-trifluorophenyl)piperidin-1-yl]carbamate

Product 1

HCID 668393791-Amino-3-(3,4,5-trifluorophenyl)piperidin-2-one hydrochloride

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 4 N hydrochloric acid in ethyl acetate (1 mL) was added to a solution of tert-butyl[2-oxo-3-(3,4,5-trifluorophenyl)piperidin-1-yl]carbamate (134 mg) in chloroform (1 mL), and the reaction solution was stirred at room temperature for three hours. The reaction solution was concentrated under reduced pressure to obtain 109 mg of the title compound. The property value of the compound is as follows.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-6720839f8c324baf93ffc7d4c15fbbeb
Source dataset
uspto-grants-2010_05
Patent number
US07713993B2

Reaction notes

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